Age / Sex : 26 / F

Chief complaint: painless palpable mass of thigh and incidentally found multiple osseous lesions

1) What is your impression?

Two weeks later, you can see the final diagnosis with a brief discussion of this case.

(Quiz는 quiz일 뿐이오니 답안은 한개만 보내주시기 바라오며, 복수의 답안을 보내주시는 분은 정답이 포함되어 있더라도 부득이 semi-correct answer로 처리토록 하겠습니다.)

Courtesy: 이재혁(Yi Jaehyuck), 경북대병원(Kyungpook National University Hospital)

Mazabraud's syndrome

Discussion

Diagnosis: Mazabraud’s syndrome

Discussion:

—  Fibrous dysplasia
+ Myxoma

—  Poly-FD +
multi M > poly-FD + single M > mono-FD + multi M > mono-FD + single M

-      
FD without myxoma: 75% monostotic

—  Unknown
mechanism & etiology

-      
Common histogenetic origin

-      
Shared abrormality in tissue metabolism

-      
Collaborative developmental error

—  3 reported cases
of malignant transformation of FD lesions to osteogenic sarcoma in patients
with Mazabraud syndrome

References:

1.    
Iwasko et al. Imaging findings in Mazabraud’s syndrome:
seven new cases. Skeletal Radiology 2002;31:81-87