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Age / Sex : 29 / F
Age/Sex: 29/F
C.C.: multiple joint pain
1) What is your impression?
Courtesy : Young Cheol Yoon, MD., Samsung Medical Center, Sungkyunkwan University School of Medicine
Diagnosis: MCTD (mixed connective tissue disease)
Discussion
Radiologic findings
- Acroosteolysis of right 1st, right 2nd, and left 2nd finger tip
- Marginal erosion of left 2nd PIP
- Joint space narrowing of bilateral radiocarpal joints
- Periarticular calcium deposition of bilateral 2nd MCP, 3rd PIP, and 3rd DIP joints
MR findings
- Abnormal high signal intensity areas with enhancement and patch distribution in bilateral vastus muscles
Diagnosis : Mixed connective tissue disease (MCTD)
Differential diagnosis :
- Rheumatoid arthritis, Scleroderma Discussion
- MCTD is characterized by overlapping clinical features of scleroderma, SLE, dermatomyositis, and RA
- Both adults and children can be affected.
- Involvement of the small joints of the hand and foot, as well as the wrist, is typical.
- The most important laboratory finding is the presence of ribonucleoprotein antibodies in serum
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