Weekly Case

Title : Case 656

Age / Sex : 38 / F


Chief complaint:


Palpable mass at left upper arm (2Y)


What is your diagnosis?

Two weeks later, you can see the final diagonosis with a brief discussion of this case (Please submit only one answer).


Courtesy : 안경식, 고려대학교 안암병원

Kyung-Sik Ahn, Korea University Anam Hospital


Diagnosis:

Mazabraud syndrome



Discussion


Findings:



  • Intramuscular myxomas with skeletal fibrous dysplasia


 


Differential Diagnosis:



  • Myxolipoma, myxoid neurofibroma, myxochondroma

  • Richly myxoid malignant tumors (myxoid liposarcoma, low grade fibromyxoid sarcoma, extraskeletal myxoid chondrosarcoma, and botryoid type rhabdomyosarcoma, etc.)


 


Discussion:


Intramuscular myxoma



  • Benign, soft tissue neoplasm with prominent myxoid stroma

  • Age: 40-70 years

  • Gender: ~ 57- 66% in female patients

  • Predilection for large muscles (thigh 51%, buttocks 7% shoulder girdle/upper arm 9%)

  • Well-circumscribed, ovoid mass

  • Fluid-sensitive MR sequences often show flame-shaped extension of signal, especially along long muscle axis

  • Multiple tumors more likely to be seen in Mazabraud syndrome


 


Fibrous dysplasia



  • Benign fibroosseous lesion

  • Diaphyseal; often extends to metaphysis and occasionally to epiphysis

  • Usually central within bone, causing varying degrees of expansion

  • Polyostotic in 15-20%

  • Polyostotic form associated with McCune-Albright syndrome, Mazabraud syndrome


 


References:


Manaster BJ, Roberts CC, Petersilge CA. Diagnostic imaging. Musculoskeletal: Non-traumatic disease. Amirsys. 2010.



Correct Answer
Total applicants 18 Correct answers 14
Name Institution
김기욱 국군수도병원, 전문의
윤유성 순천향대 부천병원, 전문의
여현정 전문의
김성진 365병원, 전문의
한유비 전문의
이진영 전문의
전인환 전문의
이혜란 전문의
김지은 서울대학교병원, 전문의
이규정 고대안암병원, 전문의
김동언 국군양주병원, 전문의
강지희 서울대학교병원, 전문의
백승진 분당차병원, 전공의
김형민 전문의
Semi-Correct Answer
Total applicants 18 Semi-Correct answers 1
송윤아 전문의


Comment